MULTIPLE ORGAN DYSFUNCTION SYNDROME IN ACUTE NECROTIZING PANCREATITIS

Acute necrotizing pancreatitis (ANP) is associated with significantlyhighermorbidity and mortality. It still difficult for the surgeon to choose schedule most appropriate treatment.In early phase of disease, surgical activity considered be ineffective high risks. The only chance save patient conduct intensive therapy in care unit, based on current pathogenetic approaches. present review analyzed understanding pathogenesis multiple organ dysfunction syndrome (MODS) acute pancreatitis. role inflammatory mediators, cytokines, biogenic amines, bradykinins, lipid peroxidation products development hypoperfusion reflected. shown that violation intestinal barrier function translocation microorganisms exacerbates endogenous intoxication contributes MODS. endothelial develops has a significant effect hemostasis. literature analysis revealed contradictory data functional coagulation anticoagulation systems at different stages disease. mechanisms intra-abdominal hypertension its multisystem negative impact are There controversialquestionof appropriatetiming indications decompression. available showed need further study work out new pathogenetically justified methods an assessment their effectiveness.